Microsoft open-sources the RetroChimera retrosynthesis model
Microsoft Research released RetroChimera code and weights under an MIT license alongside a Nature paper. The system ensembles a generative reaction model with a template-based model and learns to rerank their proposals for single-step retrosynthesis.
Why it matters: Retrosynthesis is a high-value scientific workflow where rare reaction recall and out-of-distribution robustness matter more than fluent output. An inspectable model and checkpoints let chemistry teams test those claims on their own compounds instead of…